The guests
Cameos
Former houseguests and other franchise figures who appeared during Big Brother 27.
| Guest | When | Appearance |
|---|---|---|
| Kaycee Clark | Week 2, aired Wed Jul 23, 2025 | Played the Power of Veto competition on Keanu's behalf and won it. |
| Angela Murray | Week 8, aired Wed Sep 3, 2025 | Hosted the Power of Veto competition. |
| Tyler Crispen | Week 9, aired Tue Sep 9, 2025 | Hosted the White Locust competition. |
| Zingbot | Week 10, aired Wed Sep 17, 2025 | Returned to the house and roasted the remaining houseguests. |
| Cody Calafiore | Week 12, finale aired Sun Sep 28, 2025 | Hosted the jury roundtable shown in the finale. |
| Frankie Grande | Week 12, finale aired Sun Sep 28, 2025 | Hosted Part 2 of the final Head of Household competition, and was revealed as one of the three past players behind the Mastermind. |
| Dr. Will | Week 12, finale aired Sun Sep 28, 2025 | Was unmasked as the apparent Mastermind during Part 2 of the final Head of Household competition and led off in handcuffs; the finale then revealed he had been framed. |